结直肠癌

疾病介绍

结直肠癌是累及结肠或直肠的原发性或转移性恶性肿瘤，组织学类型包括癌、淋巴瘤和肉瘤，临床绝大多数为腺癌。其发生发展涉及 APC–WNT/β-catenin 等通路的多步骤遗传与表观遗传事件，并与慢性炎症、饮食及肠道微生物群等因素交互作用；临床前研究依赖同系移植瘤、人源移植瘤/病人来源异种移植（PDX）、化学诱导与遗传易感性等多类动物模型体系。

标准定义来源：MONDO:0005575 colorectal cancer · 本体版本 2026-10-06

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