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疾病

代谢功能障碍相关脂肪性肝炎

疾病分类：hepatitis／hepatobiliary disorder／digestive system disorder／fatty liver disease／endocrine system disorder／liver disorder

疾病介绍

代谢功能障碍相关脂肪性肝炎（MASH，既往称 NASH）属于脂肪性肝病，与肥胖、糖尿病等代谢异常造成的肝内脂肪蓄积有关，是代谢功能障碍相关脂肪性肝病（MASLD）的严重类型。

标准定义来源：MONDO:0007027 metabolic dysfunction-associated steatohepatitis · 本体版本 2026-10-06

参考文献

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  5. Tripathi Anupriya, Debelius Justine, Brenner David A., Karin Michael, Loomba Rohit, Schnabl Bernd, Knight Rob. The gut-liver axis and the intersection with the microbiome. Nature reviews. Gastroenterology & hepatology. 2018.
  6. Kumar Sudhir, Verma Alok K., Rani Richa, Sharma Akanksha, Wang Jiang, Shah Shimul A., Behari Jaideep, Gonzalez Rosa Salazar, Kohli Rohit, Gandhi Chandrashekhar R.. Hepatic deficiency of augmenter of liver regeneration predisposes to nonalcoholic steatohepatitis and fibrosis. Hepatology (Baltimore, Md.). 2020.
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  11. Riordan Jesse D., Nadeau Joseph H.. Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse. Mammalian Genome. 2014.
  12. Oseini Abdul M., Cole Banumathi K., Issa Danny, Feaver Ryan E., Sanyal Arun J.. Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis. Hepatology international. 2018.
  13. Wu Jian. Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma. Oncotarget. 2016.
  14. Bettermann Kira, Hohensee Tabea, Haybaeck Johannes. Steatosis and Steatohepatitis: Complex Disorders. International Journal of Molecular Sciences. 2014.
  15. Liu Yu, Wang Da-Wei, Wang Dan, Duan Bin-Hong, Kuang Hong-Yu. Exenatide Attenuates Non-Alcoholic Steatohepatitis by Inhibiting the Pyroptosis Signaling Pathway. Frontiers in Endocrinology. 2021.
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  18. Betrapally Naga S, Gillevet Patrick M, Bajaj Jasmohan S. Gut Microbiome and Liver Disease. Translational research : the journal of laboratory and clinical medicine. 2016.
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  20. Tao Rongya, Stöhr Oliver, Tok Ozlem, Andres-Hernando Ana, Qiu Wei, He Baiyu, Wang Caixia, Grøntved Lars, Burant Charles, Hui Sheng, Lanaspa Miguel A., Stefan Norbert, Copps Kyle D., White Morris F.. Fructose and follistatin potentiate acute MASLD during complete hepatic insulin resistance. Nature Communications. 2025.

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