实验方法
组织学分析
方法说明
- 方法分类
- 组织病理
- 技术原理
- 对细胞、组织或其图像进行视觉评估，通过染色、成像和判读描述组织结构与细胞形态。
- 输入样本
- tissue
- 可回答的研究问题
- 未提供
- 输出与判读
- 组织或细胞的形态、分布、计数及染色信号等图像指标。
- 适用条件
- 用于组织切片的形态学评价，具体染色与量化指标由采用方案确定。
- 局限
- 不同染色呈现的结构与信号不同，形态学变化不能单独确定其分子机制。
已发布模型
- db/db (Lepr^db)
- ob/ob (Lep^ob)
- CC011 自发性慢性结肠炎
- DSS 诱导结肠炎模型
- AOM/DSS 结肠炎相关结肠肿瘤模型（文献参考）
- MC38 同系移植瘤模型（C57BL/6，文献参考）
- TNBS 相关结肠炎模型（大鼠，文献参考）
- Il10 基因缺失自发性结肠炎模型（文献参考）
- OVA 致敏激发过敏性气道炎症模型（文献参考）
- 屋尘螨暴露过敏性气道炎症模型（文献参考）
- AMLN 饮食相关 MASH 模型（文献参考）
- GAN 饮食相关 MASH 模型（文献参考）
- high-fat diet plus low-dose streptozotocin-induced type 2 diabetes C57BL/6J mouse
- ApoE-deficient mouse
- ApoE-deficient C57BL/6J mouse
- ApoE-deficient C57BL/6 mouse
- LDL receptor-deficient mouse
- LDL receptor-deficient C57BL/6 mouse
- LDL receptor-deficient C57BL/6J mouse
- Cholesterol-fed New Zealand White rabbit
- Watanabe heritable hyperlipidemic rabbit
- LDL receptor-deficient rabbit
- Balloon-injured rabbit artery
- High-fat diet-fed C57BL/6 mouse
- High-fat diet-fed mouse
- PCSK9-AAV hypercholesterolemic mouse
- ApoE3-Leiden mouse
- ApoE-deficient Fbn1 C1039G+/- mouse
- Cholesterol-fed rabbit
- Tandem stenosis (TS) mouse model
- high-fat diet-fed cynomolgus monkey
- high-fat diet-fed pig
- cdkn2a deficiency mouse
- lox-1 deficiency with ldl receptor deficiency mouse
- lox-1 overexpression with apoe deficiency mouse
- ovariectomy with cholesterol and heated vegetable oil diet Sprague-Dawley rat
- cetp deficiency rabbit
- apoe*3leiden.cetp transgenic hyperlipidemia mouse
- ldl receptor deficiency with human apob-100 transgene mouse
- abca1 and abcg1 deficiency mouse
- atg5 deficiency mouse
- qa-1 d227k point mutation mouse
- apoe and ccr7 deficiency mouse
- ldl receptor and ccr7 deficiency mouse
- ldl receptor deficiency with cxcl1 deficiency mouse
- hypomorphic sr-b1 deficiency mouse
- sr-b1 and apoe deficiency mouse
- sr-b1 deficiency mouse
- mmp-12 deficiency with apoe deficiency mouse
- mmp-3 deficiency with apoe deficiency mouse
- nox5 deletion New Zealand White rabbit
- pon1 overexpression mouse
- ucp2-deficient bone marrow transplantation mouse
- endothelial piezo1 deletion with ldl receptor deficiency mouse
- endothelial plxnd1 deletion mouse
- partial carotid ligation with pcsk9 overexpression C57BL/6 mouse
- jak2 v617f clonal hematopoiesis mouse
- streptozotocin-induced diabetes with adipose ucp1 expression pig
- tet2 clonal hematopoiesis mouse
- ucp1 deficiency with apoe deficiency mouse
- hiv transgene with apoe deficiency mouse
- genetic plaque instability model with inducible angiotensin ii mouse
- high-fat diet-fed golden Syrian hamster
- LDL receptor-deficient golden hamster
- aav-crispr somatic ldlr disruption mouse
- ldl receptor deficiency with loss of apob mrna editing mouse
- sr-bi and ldl receptor deficiency mouse
- sr-bi deficiency with hypomorphic apoe mouse
- apoe and par2 deficiency mouse
- ldl receptor and par2 deficiency mouse
- aortic transplantation mouse model
- Golden Syrian hamster
- ApoE deficiency with AT1 receptor disruption mouse
- PCSK9-AAV hypercholesterolemia C57BL/6 mouse
- AAV8-PCSK9 with Western-type diet mouse
- CDAHFD 饮食诱导 NASH 模型（C57BL/6J 小鼠）
- GALT 缺失经典半乳糖血症模型（SD 大鼠）
- 高脂高果糖饮食诱导代谢综合征模型（C57BL/6 小鼠）
- A/J 小鼠鼻内 OVA 哮喘模型（文献参考）
- 香烟暴露咳嗽变异型气道模型（文献参考）
- 烟曲霉致敏咳嗽变异型哮喘模型（文献参考）
- 慢性高剂量 Der p 鼻内激发哮喘模型（C57BL/6，文献参考）
已发布方案版本
- 动脉组织石蜡切片 H&E 染色
来源版本：protocols.io · vv1 · Nathalia L. Oliveira; samantha.gruenheid · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
- Hematoxylin and Eosin (H&E) staining for histopathology
来源版本：protocols.io · vv1 · Nathalia L. Oliveira; samantha.gruenheid · Creative Commons Attribution (CC BY)，来源未声明数字许可版本号
- Hematoxylin and Eosin (H&E) staining for histopathology
来源版本：protocols.io · vv1 · Nathalia L. Oliveira; samantha.gruenheid · Creative Commons Attribution (CC BY)，来源未声明数字许可版本号
- Hematoxylin and Eosin (H&E) staining for histopathology
来源版本：protocols.io · vv1 · Nathalia L. Oliveira; samantha.gruenheid · Creative Commons Attribution (CC BY)，来源未声明数字许可版本号
参考文献
- histological assay (OBI:0600020; OBI 2026-05-08)
- histological assay (OBI:0600020), OBI 2026-05-08
- Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway
- An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2016
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