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Disease

metabolic dysfunction-associated steatohepatitis

Disease classification：hepatitis; hepatobiliary disorder; digestive system disorder; fatty liver disease; endocrine system disorder; liver disorder

About this disease

Metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis or NASH) is a type of fatty liver disease. It often develops due to a metabolic disorder, such as obesity or diabetes, resulting in a toxic buildup of fat in the liver. It is the most severe form of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as nonalcoholic fatty liver disease or NAFLD).

Standard definition source：MONDO:0007027 metabolic dysfunction-associated steatohepatitis · ontology version 2026-10-06

References

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  5. Tripathi Anupriya, Debelius Justine, Brenner David A., Karin Michael, Loomba Rohit, Schnabl Bernd, Knight Rob. The gut-liver axis and the intersection with the microbiome. Nature reviews. Gastroenterology & hepatology. 2018.
  6. Kumar Sudhir, Verma Alok K., Rani Richa, Sharma Akanksha, Wang Jiang, Shah Shimul A., Behari Jaideep, Gonzalez Rosa Salazar, Kohli Rohit, Gandhi Chandrashekhar R.. Hepatic deficiency of augmenter of liver regeneration predisposes to nonalcoholic steatohepatitis and fibrosis. Hepatology (Baltimore, Md.). 2020.
  7. Zhao Xu-Yun, Xiong Xuelian, Liu Tongyu, Mi Lin, Peng Xiaoling, Rui Crystal, Guo Liang, Li Siming, Li Xiaoying, Lin Jiandie D.. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nature Communications. 2018.
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  9. Santhekadur Prasanna K., Kumar Divya P., Sanyal Arun J.. PRECLINICAL MODELS OF NONALCOHOLIC FATTY LIVER DISEASE. Journal of hepatology. 2017.
  10. Yanguas Sara Crespo, Cogliati Bruno, Willebrords Joost, Maes Michaël, Colle Isabelle, van den Bossche Bert, de Oliveira Claudia Pinto Marques Souza, Andraus Wellington, Alves Venâncio Avancini Ferreira, Leclercq Isabelle, Vinken Mathieu. Experimental models of liver fibrosis. Archives of toxicology. 2015.
  11. Riordan Jesse D., Nadeau Joseph H.. Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse. Mammalian Genome. 2014.
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  13. Wu Jian. Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma. Oncotarget. 2016.
  14. Bettermann Kira, Hohensee Tabea, Haybaeck Johannes. Steatosis and Steatohepatitis: Complex Disorders. International Journal of Molecular Sciences. 2014.
  15. Liu Yu, Wang Da-Wei, Wang Dan, Duan Bin-Hong, Kuang Hong-Yu. Exenatide Attenuates Non-Alcoholic Steatohepatitis by Inhibiting the Pyroptosis Signaling Pathway. Frontiers in Endocrinology. 2021.
  16. Ibrahim Samar H., Hirsova Petra, Malhi Harmeet, Gores Gregory J.. Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame. Digestive diseases and sciences. 2015.
  17. Wahlang Banrida, Beier Juliane I., Clair Heather B., Bellis-Jones Heather J., Falkner K. Cameron, McClain Craig J., Cave Matt C.. Toxicant-associated Steatohepatitis. Toxicologic pathology. 2012.
  18. Betrapally Naga S, Gillevet Patrick M, Bajaj Jasmohan S. Gut Microbiome and Liver Disease. Translational research : the journal of laboratory and clinical medicine. 2016.
  19. Takakura Kazuki, Oikawa Tsunekazu, Tomita Yoichi, Mizuno Yusuke, Nakano Masanori, Saeki Chisato, Torisu Yuichi, Saruta Masayuki. Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma. World Journal of Gastroenterology. 2018.
  20. Tao Rongya, Stöhr Oliver, Tok Ozlem, Andres-Hernando Ana, Qiu Wei, He Baiyu, Wang Caixia, Grøntved Lars, Burant Charles, Hui Sheng, Lanaspa Miguel A., Stefan Norbert, Copps Kyle D., White Morris F.. Fructose and follistatin potentiate acute MASLD during complete hepatic insulin resistance. Nature Communications. 2025.

Applicable models

Models come from published, verified disease–model relations only.

Model consultation