学习与记忆评估

What this technique is

Category

Physiology & behavior

Principle

通过对活体动物的学习或记忆反应进行评估，测量相应的神经系统功能。

Input samples

mouse · rat

Research questions

Not provided

Output and readout

按具体范式输出逃避潜伏期、目标区域停留时间、平台位置穿越次数或自发交替率，反映相应的学习与记忆表现。

Applicability

用于小鼠和大鼠的学习、空间记忆或工作记忆评价；不同记忆维度采用对应的行为学范式。

Limitations

不同范式评价的记忆维度不同，指标不能直接互换；解释行为变化时需结合活动能力，避免将活动受限误判为记忆下降。

Standard concept source：OBI:0003709 · OBI · 2026-05-08

已发布模型

• C57 小鼠 MCAO 线栓模型
• SD 大鼠 MCAO 线栓模型
• 5xFAD 转基因模型
• 3xTg-AD 转基因模型
• Tg2576 转基因淀粉样蛋白模型（APP695 Swedish）
• J20 转基因淀粉样蛋白模型（APPSwInd，PDGFB）
• TgCRND8 转基因淀粉样蛋白模型（Swedish+Indiana，PrP）
• Sprague-Dawley ICV-STZ rat
• APOE4
• McGill-R-Thy1-APP
• App NL
• Tg4-42
• TgF344-AD
• Wistar ICV-STZ rat
• rTg4510
• bilateral common carotid artery stenosis C57BL/6 mouse
• transient middle cerebral artery occlusion Wistar rat
• permanent distal middle cerebral artery occlusion C57BL/6J mouse
• transient middle cerebral artery occlusion C57BL/6J mouse
• asymmetric common carotid artery surgery C57BL/6J mouse
• bilateral common carotid artery stenosis C57BL/6J mouse
• GALT 缺失经典半乳糖血症模型（SD 大鼠）

Published protocol versions

• 大鼠 Morris 水迷宫空间定位与再学习测定

  Source version：protocols.io · vv1 · Aroa S Maroto; Egoa Ugarte Perez; Antonio Cerdán Cerdá; Silvia De Santis · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

• 小鼠 Morris 水迷宫空间学习与记忆测定

  Source version：protocols.io · vv1 · Sarah van Veen; Zsuzsanna Callaerts-Végh · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

• 小鼠 Morris 水迷宫空间学习与记忆测定

  Source version：protocols.io · vv1 · Sarah van Veen; Zsuzsanna Callaerts-Végh · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

• 大鼠 Morris 水迷宫空间定位与再学习测定

  Source version：protocols.io · vv1 · Aroa S Maroto; Egoa Ugarte Perez; Antonio Cerdán Cerdá; Silvia De Santis · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

References

1. assessment of learning and/or memory response in an organism (OBI:0003709), OBI 2026-05-08
2. Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease
3. Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer’s disease rats
4. Y maze protocol, protocols.io, version 1; native steps 1919924–1919927