Dry bedding for a water-maze holding cage

Quality standard: The source explicitly requires dry bedding but does not report bedding material, mass or quantity per animal.
Use information: Return animals to a holding cage with dry bedding between trials.

References

protocols.io v1; step protocolsio-13017485; verbatim source: holding cage with dry bedding

Used in these protocol BOMs

Morris water maze assessment of spatial learning and memory in miceprotocol #188 · revision 12
Source version：protocols.io · v1 · Sarah van Veen; Zsuzsanna Callaerts-Végh · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Learning and Memory Assessment
This reagent's uses & amounts
- Training trials · Return animals to a holding cage with dry bedding between trials. · Not reported in the source · The source explicitly requires dry bedding but does not report bedding material, mass or quantity per animal.
Associated models: 1515 protocol→model record(s)15 verified · 0 candidate
Model → research topic：12 verified · 3 candidate。These statuses apply to individual relationships, not to this reagent.
Recorded use and applicability limits
- Protocol → model：bilateral common carotid artery stenosis C57BL/6J mouse：
  Morris water maze assessment of spatial learning and memory in C57BL/6J mice after chronic hypoperfusion induced by bilateral common carotid artery stenosis.
- Protocol → model：bilateral common carotid artery stenosis C57BL/6J mouse：
  Age：Adult (specific age in weeks not reported by the source)
- Protocol → model：bilateral common carotid artery stenosis C57BL/6J mouse；Protocol → model：asymmetric common carotid artery surgery C57BL/6J mouse；Protocol → model：bilateral common carotid artery stenosis C57BL/6 mouse；Protocol → model：permanent distal middle cerebral artery occlusion C57BL/6J mouse；Protocol → model：transient middle cerebral artery occlusion C57BL/6J mouse；Protocol → model：C57 mouse MCAO suture model：
  Tissue：Brain/Hippocampus (spatial learning and memory)
- Model → research topic：bilateral common carotid artery stenosis C57BL/6J mouse → ischemic stroke：
  Bilateral common carotid artery stenosis produces chronic hypoperfusion and white-matter injury in C57BL/6J mice; it is not an acute focal MCA infarct model.
- Protocol → model：asymmetric common carotid artery surgery C57BL/6J mouse：
  Assessment of spatial learning and memory using the Morris water maze after unilateral common carotid artery surgery in C57BL/6J mice.
- Protocol → model：asymmetric common carotid artery surgery C57BL/6J mouse；Protocol → model：bilateral common carotid artery stenosis C57BL/6 mouse；Protocol → model：permanent distal middle cerebral artery occlusion C57BL/6J mouse；Protocol → model：transient middle cerebral artery occlusion C57BL/6J mouse；Protocol → model：C57 mouse MCAO suture model：
  Age：Adult (specific age in weeks not reported by source)
- Model → research topic：asymmetric common carotid artery surgery C57BL/6J mouse → ischemic stroke：
  Asymmetric common carotid artery surgery produces chronic white-matter infarct-related damage and cognitive/motor dysfunction; it is a hypoperfusion reference model, not acute territorial stroke.
- Protocol → model：bilateral common carotid artery stenosis C57BL/6 mouse：
  Research on spatial learning and memory associated with chronic cerebral hypoperfusion.
- Model → research topic：bilateral common carotid artery stenosis C57BL/6 mouse → ischemic stroke：
  Bilateral common carotid artery stenosis produces chronic hypoperfusion and white-matter injury in C57BL/6 mice; it is a hypoperfusion reference model, not an acute focal MCA infarct.
- Protocol → model：permanent distal middle cerebral artery occlusion C57BL/6J mouse：
  Assessment of long-term spatial memory recovery using the Morris water maze after permanent distal MCAO in C57BL/6J mice.
- Model → research topic：permanent distal middle cerebral artery occlusion C57BL/6J mouse → ischemic stroke：
  Study on White Matter Repair and Functional Recovery After Permanent Distal Middle Cerebral Artery Occlusion in C57BL/6J Mice.
- Protocol → model：transient middle cerebral artery occlusion C57BL/6J mouse：
  Morris water maze assessment of spatial learning and memory after MCAO in C57BL/6J mice.
- Model → research topic：transient middle cerebral artery occlusion C57BL/6J mouse → ischemic stroke：
  Male C57BL/6J mice subjected to 90 min intraluminal MCAO; sham mice underwent identical surgery without filament insertion.
- Protocol → model：C57 mouse MCAO suture model：
  Morris water maze was used to assess spatial learning and memory in C57BL/6 mice after MCAO.
- Model → research topic：C57 mouse MCAO suture model → ischemic stroke：
  Transient MCAO reperfusion model in C57 mice for the study of ischemic brain injury.
- Protocol → model：3xTg-AD transgenic model；Protocol → model：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP)；Protocol → model：J20 transgenic amyloidosis model (APPSwInd, PDGFB)；Protocol → model：5xFAD transgenic model；Protocol → model：Tg2576 transgenic amyloid model (APP695 Swedish)；Protocol → model：App NL：
  Spatial learning and reference memory assessment.
- Protocol → model：3xTg-AD transgenic model：
  Age：Intervention started at 3 months of age, followed by behavioral testing
- Protocol → model：3xTg-AD transgenic model；Protocol → model：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP)；Protocol → model：J20 transgenic amyloidosis model (APPSwInd, PDGFB)；Protocol → model：5xFAD transgenic model；Protocol → model：Tg2576 transgenic amyloid model (APP695 Swedish)；Protocol → model：App NL：
  Tissue：Live mice (behavioral studies)
- Model → research topic：3xTg-AD transgenic model → Alzheimer disease：
  The 3xTg-AD transgenic model is used for research on Alzheimer's disease-related amyloid and tau pathology.
- Protocol → model：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP)：
  Age：77–85 days of age
- Protocol → model：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP)；Protocol → model：APOE4；Protocol → model：rTg4510：
  Sex：Mixed
- Model → research topic：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP) → Alzheimer disease：
  Intervention Study of Early-Onset Strong Amyloid Deposition and Cognitive Impairment Paradigm (TgCRND8)
- Protocol → model：J20 transgenic amyloidosis model (APPSwInd, PDGFB)：
  Age：4–6 months of age
- Protocol → model：J20 transgenic amyloidosis model (APPSwInd, PDGFB)；Protocol → model：Tg2576 transgenic amyloid model (APP695 Swedish)：
  Sex：Female
- Model → research topic：J20 transgenic amyloidosis model (APPSwInd, PDGFB) → Alzheimer disease：
  J20 (APP Swedish+Indiana double mutation, PDGFB promoter) reference model for amyloid pathology and synaptotoxicity studies; applicability is limited to JAX strain records and PMID:10818140 controlled studies
- Protocol → model：5xFAD transgenic model：
  Age：4. 9 months of age
- Model → research topic：5xFAD transgenic model → Alzheimer disease：
  The 5xFAD transgenic model is used for research on Alzheimer's disease-related amyloid pathology and neurodegenerative changes.
- Protocol → model：Tg2576 transgenic amyloid model (APP695 Swedish)：
  Age：20 months of age
- Model → research topic：Tg2576 transgenic amyloid model (APP695 Swedish) → Alzheimer disease：
  Age-dependent memory decline and amyloid plaque study driven by APP Swedish mutation overexpression (Tg2576)
- Protocol → model：App NL：
  Age：24 months of age
- Protocol → model：App NL：
  Sex：Male
- Model → research topic：App NL → Alzheimer disease：
  Investigate the relationship between App Swedish mutation, Aβ oligomer accumulation, and cognitive phenotype.
- Protocol → model：APOE4：
  In recipients receiving bone marrow cells from APP/PS1 and human APOE4 background donors, the Morris water maze was used to evaluate human APOE4-related changes in spatial learning and reference memory, and swimming speed was incorporated to distinguish the influence of locomotor ability.
- Protocol → model：APOE4：
  Age：Bone marrow cell transplantation at 3 months of age, evaluation at 12 months of age
- Protocol → model：APOE4：
  Tissue：Live mice; spatial learning and memory assessment in the context of bone marrow transplantation
- Model → research topic：APOE4 → Alzheimer disease：
  To study the effects of APOE4 on peripheral Aβ brain transport, the blood-brain barrier, and cognitive performance.
- Protocol → model：Tg4-42：
  The water maze was used to evaluate spatial learning and reference memory in Tg4-42 mice, to distinguish between different ages in months and zygosity, and to assess sensorimotor factors through the visible platform and swimming speed.
- Protocol → model：Tg4-42：
  Age：Hemizygous at 3, 8, and 12 months of age; homozygous at 3 and 8 months of age
- Protocol → model：Tg4-42：
  Tissue：Live mice; evaluation of spatial learning and reference memory
- Model → research topic：Tg4-42 → Alzheimer disease：
  To study Aβ4-42-related alterations in hippocampal neurogenesis, as well as the effects of activity conditions on the structure of the dentate gyrus and neuronal generation.
- Protocol → model：rTg4510：
  Evaluate the spatial learning and reference memory of rTg4510 mice using the water maze, and combine with the visible platform and swimming speed to check sensorimotor factors; the genetic backgrounds compared in the study are explained separately.
- Protocol → model：rTg4510：
  Age：2.5 months of age
- Protocol → model：rTg4510：
  Tissue：Live mice; F1 FVB/N×129S6 and separately compared rTg4510B6 background
- Model → research topic：rTg4510 → Alzheimer disease：
  Study the staged effects of tau pathology, neurodegeneration, and tau expression suppression; not suitable for evaluating Aβ pathology alone.
Show 15 model association(s)
bilateral common carotid artery stenosis C57BL/6J mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:31817864; https://pubmed.ncbi.nlm.nih.gov/31817864/
Age：Adult (specific age in weeks not reported by the source)Tissue：Brain/Hippocampus (spatial learning and memory)
Morris water maze assessment of spatial learning and memory in C57BL/6J mice after chronic hypoperfusion induced by bilateral common carotid artery stenosis.
Related research topics: 1 (0 verified · 1 candidate)
· ischemic stroke · Candidate (not internally validated)
This model's applicability to this disease
Status：Candidate (not internally validated)· Evidence type：Literature evidence· Source：PMID:31817864; https://pubmed.ncbi.nlm.nih.gov/31817864/
Bilateral common carotid artery stenosis produces chronic hypoperfusion and white-matter injury in C57BL/6J mice; it is not an acute focal MCA infarct model.
asymmetric common carotid artery surgery C57BL/6J mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:31817864; https://pubmed.ncbi.nlm.nih.gov/31817864/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Assessment of spatial learning and memory using the Morris water maze after unilateral common carotid artery surgery in C57BL/6J mice.
Related research topics: 1 (0 verified · 1 candidate)
· ischemic stroke · Candidate (not internally validated)
This model's applicability to this disease
Status：Candidate (not internally validated)· Evidence type：Literature evidence· Source：PMID:31817864; https://pubmed.ncbi.nlm.nih.gov/31817864/
Asymmetric common carotid artery surgery produces chronic white-matter infarct-related damage and cognitive/motor dysfunction; it is a hypoperfusion reference model, not acute territorial stroke.
bilateral common carotid artery stenosis C57BL/6 mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/31817864/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Research on spatial learning and memory associated with chronic cerebral hypoperfusion.
Related research topics: 1 (0 verified · 1 candidate)
· ischemic stroke · Candidate (not internally validated)
This model's applicability to this disease
Status：Candidate (not internally validated)· Evidence type：Literature evidence· Source：PMID:34797519; https://pubmed.ncbi.nlm.nih.gov/34797519/
Bilateral common carotid artery stenosis produces chronic hypoperfusion and white-matter injury in C57BL/6 mice; it is a hypoperfusion reference model, not an acute focal MCA infarct.
permanent distal middle cerebral artery occlusion C57BL/6J mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:42529831; https://pubmed.ncbi.nlm.nih.gov/42529831/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Assessment of long-term spatial memory recovery using the Morris water maze after permanent distal MCAO in C57BL/6J mice.
Related research topics: 1 (1 verified · 0 candidate)
· ischemic stroke · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/42529831/
Study on White Matter Repair and Functional Recovery After Permanent Distal Middle Cerebral Artery Occlusion in C57BL/6J Mice.
transient middle cerebral artery occlusion C57BL/6J mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:42677156; https://pubmed.ncbi.nlm.nih.gov/42677156/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Morris water maze assessment of spatial learning and memory after MCAO in C57BL/6J mice.
Related research topics: 1 (1 verified · 0 candidate)
· ischemic stroke · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1186/s13041-017-0296-9
Male C57BL/6J mice subjected to 90 min intraluminal MCAO; sham mice underwent identical surgery without filament insertion.
C57 mouse MCAO suture model · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:42544301; https://pubmed.ncbi.nlm.nih.gov/42544301/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Morris water maze was used to assess spatial learning and memory in C57BL/6 mice after MCAO.
Related research topics: 1 (1 verified · 0 candidate)
· ischemic stroke · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:37786756; https://pubmed.ncbi.nlm.nih.gov/37786756/; DOI:10.1002/ibra.12128
Transient MCAO reperfusion model in C57 mice for the study of ischemic brain injury.
3xTg-AD transgenic model · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/29725016/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：Intervention started at 3 months of age, followed by behavioral testingTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:12895417; https://pubmed.ncbi.nlm.nih.gov/12895417/; DOI:10.1016/s0896-6273(03)00434-3
The 3xTg-AD transgenic model is used for research on Alzheimer's disease-related amyloid and tau pathology.
TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP) · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/26902204/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：77–85 days of ageSex：MixedTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:37887303; DOI:10.3390/cells12202459; https://pubmed.ncbi.nlm.nih.gov/37887303/
Intervention Study of Early-Onset Strong Amyloid Deposition and Cognitive Impairment Paradigm (TgCRND8)
J20 transgenic amyloidosis model (APPSwInd, PDGFB) · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/28700937/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：4–6 months of ageSex：FemaleTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:10818140; DOI:10.1523/JNEUROSCI.20-11-04050.2000; https://pubmed.ncbi.nlm.nih.gov/10818140/
J20 (APP Swedish+Indiana double mutation, PDGFB promoter) reference model for amyloid pathology and synaptotoxicity studies; applicability is limited to JAX strain records and PMID:10818140 controlled studies
5xFAD transgenic model · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/26942905/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：4. 9 months of ageTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:17021169; https://pubmed.ncbi.nlm.nih.gov/17021169/; DOI:10.1523/jneurosci.1202-06.2006
The 5xFAD transgenic model is used for research on Alzheimer's disease-related amyloid pathology and neurodegenerative changes.
Tg2576 transgenic amyloid model (APP695 Swedish) · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/25100745/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：20 months of ageSex：FemaleTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:8810256; DOI:10.1126/science.274.5284.99; https://pubmed.ncbi.nlm.nih.gov/8810256/
Age-dependent memory decline and amyloid plaque study driven by APP Swedish mutation overexpression (Tg2576)
App NL · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/30320577/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：24 months of ageSex：MaleTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.3233/JAD-180410
Investigate the relationship between App Swedish mutation, Aβ oligomer accumulation, and cognitive phenotype.
APOE4 · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 40906458, Methods and Materials and Figure 7: 3-month-old recipients were transplanted, cognitive assessment was performed at 12 months of age, and males and females were used in a balanced manner; the recipient APOE4 genotype and the transplantation background were each retained. PIO5jyl84zk7g2w/v1 was used as the mouse reference for implementation, not as a parameter-by-parameter reproduction of the original article; no claim is made that the original article used ACUSOL OP301.
Age：Bone marrow cell transplantation at 3 months of age, evaluation at 12 months of ageSex：MixedTissue：Live mice; spatial learning and memory assessment in the context of bone marrow transplantation
In recipients receiving bone marrow cells from APP/PS1 and human APOE4 background donors, the Morris water maze was used to evaluate human APOE4-related changes in spatial learning and reference memory, and swimming speed was incorporated to distinguish the influence of locomotor ability.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1111/acel.70205
To study the effects of APOE4 on peripheral Aβ brain transport, the blood-brain barrier, and cognitive performance.
Tg4-42 · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 23685882, PMC3722453, Spatial reference memory by Morris water maze: hemizygotes at 3/8/12 months of age, homozygotes at 3/8 months of age; sex was matched between groups but the specific sex composition of this cohort was not reported. The complete reference memory protocol of PIO5jyl84zk7g2w/v1 was used, not a parameter-by-parameter reproduction of the original article; it is not inferred that the original article used ACUSOL OP301.
Age：Hemizygous at 3, 8, and 12 months of age; homozygous at 3 and 8 months of ageTissue：Live mice; evaluation of spatial learning and reference memory
The water maze was used to evaluate spatial learning and reference memory in Tg4-42 mice, to distinguish between different ages in months and zygosity, and to assess sensorimotor factors through the visible platform and swimming speed.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1177/1759091419892692
To study Aβ4-42-related alterations in hippocampal neurogenesis, as well as the effects of activity conditions on the structure of the dentate gyrus and neuronal generation.
rTg4510 · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 24428919, PMC3896770, Mice and Morris water maze: 2.5-month-old rTg4510, rTg4510B6, and non-transgenic littermate controls, both males and females included; the original and B6 variant backgrounds were not mixed into a single strain. Implemented using the PIO5jyl84zk7g2w/v1 reference, not a parameter-by-parameter reproduction of the original article; no claim is made that the original article used ACUSOL OP301.
Age：2.5 months of ageSex：MixedTissue：Live mice; F1 FVB/N×129S6 and separately compared rTg4510B6 background
Evaluate the spatial learning and reference memory of rTg4510 mice using the water maze, and combine with the visible platform and swimming speed to check sensorimotor factors; the genetic backgrounds compared in the study are explained separately.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.3390/biomedicines14071609
Study the staged effects of tau pathology, neurodegeneration, and tau expression suppression; not suitable for evaluating Aβ pathology alone.

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Reagent：Dry bedding for a water-maze holding cage

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