Diseases
阿尔兹海默症 (AD) 模型
About this disease
Disease classification：dementia; psychiatric disorder; cognitive disorder; central nervous system disorder; nervous system disorder; neurodegenerative disease
A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Standard definition source：MONDO:0004975 Alzheimer disease · ontology version 2026-10-06
Applicable models (published, verified)
- 5xFAD 转基因模型 · 5xFAD 转基因模型用于阿尔茨海默病相关淀粉样病理和神经退行性改变研究。 · Verified applicability
- 3xTg-AD 转基因模型 · 3xTg-AD 转基因模型用于阿尔茨海默病相关淀粉样蛋白与 tau 病理研究。 · Verified applicability
- CC × 5xFAD F1 杂交队列 · CC×5xFAD F1 队列用于研究宿主遗传背景对淀粉样病理、胶质细胞反应及轴突损伤表型韧性的修饰作用。 · Verified applicability
- APP/PS1 参考品系（B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax） · APP/PS1 作为阿尔茨海默病机制与临床前研究的文献参考模型；其 AD 疾病模型适用性来自 MGI 品系疾病表标注，不代表吉田内部验证、库存或实际实验结果 · Verified applicability
- Tg2576 转基因淀粉样蛋白模型（APP695 Swedish） · APP Swedish 突变过表达驱动的年龄依赖记忆减退与淀粉样斑研究（Tg2576） · Verified applicability
- APP23 转基因淀粉样蛋白模型（Swedish，神经元启动子） · 淀粉样沉积与脑淀粉样血管病（CAA）研究的神经元过表达模型（APP23） · Verified applicability
- J20 转基因淀粉样蛋白模型（APPSwInd，PDGFB） · J20（APP Swedish+Indiana 双突变，PDGFB 启动子）淀粉样病理与突触毒性研究的参考模型；适用性以 JAX 品系记录及 PMID:10818140 对照研究为限 · Verified applicability
- PDAPP 转基因淀粉样蛋白模型（APP V717F Indiana） · Aβ42 比例升高驱动的渐进淀粉样病理研究（PDAPP V717F） · Verified applicability
- TgCRND8 转基因淀粉样蛋白模型（Swedish+Indiana，PrP） · 早发强烈淀粉样沉积与认知损害范式的干预研究（TgCRND8） · Verified applicability
- App NL-F 敲入模型（Swedish+Iberian 点突变） · 人源化 App 敲入生理水平 Aβ 病理与神经炎症研究（App NL-F） · Verified applicability
- App NL-G-F 敲入模型（Swedish+Arctic+Iberian） · 人源化 App 敲入激进 Aβ 沉积级联研究（App NL-G-F） · Verified applicability
- Sprague-Dawley ICV-STZ rat · 研究星形胶质细胞、AQP4极化分布、Aβ清除与认知功能之间的联系，以及候选干预对这些表型的影响。 · Verified applicability
- APOE4 · 研究APOE4对外周Aβ脑内转运、血脑屏障及认知表现的影响。 · Verified applicability
- McGill-R-Thy1-APP · 纵向研究Aβ积累、空间记忆、脑网络连接及PET代谢或淀粉样信号之间的关系。 · Verified applicability
- App NL · 研究App Swedish突变、Aβ寡聚体积累与认知表型之间的关系。 · Verified applicability
- Tg4-42 · 研究Aβ4-42相关的海马神经发生改变，以及活动条件对齿状回结构和神经元生成的影响。 · Verified applicability
- TgF344-AD · 研究早期行为变化、工作记忆与结构或功能脑网络之间的联系，探索影像与认知指标的联合评价。 · Verified applicability
- Wistar ICV-STZ rat · 研究脑能量代谢、神经损伤与认知功能的联系，评估候选干预对相关表型的影响。 · Verified applicability
- rTg4510 · 研究 tau 病理、神经退变及 tau 表达抑制的阶段性影响；不适用于单独评价 Aβ 病理。 · Verified applicability
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