Towels for drying experimental animals

Quality standard: The source lists towels as materials; the mouse protocol guidelines specify a warm towel. Material, dimensions and quantity per animal are not reported.
Use information: Dry animals after removal from the water between maze trials, following the warming arrangements in the applicable protocol.

References

Used in these protocol BOMs

Morris water maze assessment of spatial navigation and relearning in ratsprotocol #182 · revision 6
Source version：protocols.io · v1 · Aroa S Maroto; Egoa Ugarte Perez; Antonio Cerdán Cerdá; Silvia De Santis · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Learning and Memory Assessment
This reagent's uses & amounts
- Place the animal at the selected starting point facing the center of the pool · Dry animals after removal from the water between maze trials, following the warming arrangements in the applicable protocol. · Not reported in the source · The source lists towels as materials for drying animals after removal from the water; material, dimensions and quantity are not reported.
Associated models: 77 protocol→model record(s)7 verified · 0 candidate
Model → research topic：7 verified · 0 candidate。These statuses apply to individual relationships, not to this reagent.
Recorded use and applicability limits
- Protocol → model：Wistar ICV-STZ rat：
  Evaluating the spatial learning and localization performance of Wistar ICV-STZ rats using the water maze platform latency and swimming trajectories.
- Protocol → model：Wistar ICV-STZ rat：
  Age：3–4 months of age
- Protocol → model：Wistar ICV-STZ rat；Protocol → model：GALT-deficient classic galactosemia model (SD rat)：
  Sex：Male
- Protocol → model：Wistar ICV-STZ rat：
  Tissue：Wistar ICV-STZ rats; the original study used male animals.
- Model → research topic：Wistar ICV-STZ rat → Alzheimer disease：
  Study the connections among brain energy metabolism, neural injury, and cognitive function, and evaluate the effects of candidate interventions on the relevant phenotypes.
- Protocol → model：TgF344-AD：
  Compare the platform-reaching latency in successive place navigation trials to evaluate the spatial relearning performance of TgF344-AD rats.
- Protocol → model：TgF344-AD：
  Age：4.29–6.52 months of age
- Protocol → model：TgF344-AD；Protocol → model：McGill-R-Thy1-APP：
  Sex：Mixed
- Protocol → model：TgF344-AD：
  Tissue：TgF344-AD rats; the original study included male and female animals and wild-type controls.
- Model → research topic：TgF344-AD → Alzheimer disease：
  Investigate the associations between early behavioral changes, working memory, and structural or functional brain networks, and explore the joint evaluation of imaging and cognitive metrics.
- Protocol → model：McGill-R-Thy1-APP：
  Evaluate the spatial learning and memory of McGill-R-Thy1-APP rats using water maze positioning performance, and note the impact of visual and swimming abilities on behavioral readouts.
- Protocol → model：McGill-R-Thy1-APP：
  Age：9–11 months of age and 16–19 months of age
- Protocol → model：McGill-R-Thy1-APP：
  Tissue：McGill-R-Thy1-APP homozygous rats; the original study included male and female animals and WT Wistar controls.
- Model → research topic：McGill-R-Thy1-APP → Alzheimer disease：
  A longitudinal study of the relationship between Aβ accumulation, spatial memory, brain network connectivity, and PET metabolic or amyloid signals.
- Protocol → model：Sprague-Dawley ICV-STZ rat：
  Evaluate spatial positioning and relearning based on the latency to the platform and swimming trajectories, focusing on the spatial learning and memory performance of the model.
- Protocol → model：Sprague-Dawley ICV-STZ rat：
  Age：Adult
- Protocol → model：Sprague-Dawley ICV-STZ rat：
  Sex：Female
- Protocol → model：Sprague-Dawley ICV-STZ rat：
  Tissue：Sprague–Dawley ICV-STZ rats; the original study used adult female animals.
- Model → research topic：Sprague-Dawley ICV-STZ rat → Alzheimer disease：
  Investigate the connections among astrocytes, AQP4 polarized distribution, Aβ clearance, and cognitive function, as well as the effects of candidate interventions on these phenotypes.
- Protocol → model：SD rat MCAO suture model：
  Assessment of long-term spatial learning and memory using the Morris water maze after transient MCAO in SD rats.
- Protocol → model：SD rat MCAO suture model；Protocol → model：transient middle cerebral artery occlusion Wistar rat：
  Age：Adult (specific age in weeks not reported by source)
- Protocol → model：SD rat MCAO suture model；Protocol → model：transient middle cerebral artery occlusion Wistar rat：
  Tissue：Brain/Hippocampus (spatial learning and memory)
- Model → research topic：SD rat MCAO suture model → ischemic stroke：
  The transient MCAO reperfusion model in SD rats is used for the study of ischemic brain injury.
- Protocol → model：transient middle cerebral artery occlusion Wistar rat：
  Morris water maze was used to assess spatial learning and memory in Wistar rats after MCAO.
- Model → research topic：transient middle cerebral artery occlusion Wistar rat → ischemic stroke：
  Transient MCAO for 90 min without BCCAo served as the stroke-only comparison group.
- Protocol → model：GALT-deficient classic galactosemia model (SD rat)：
  Evaluation of Morris water maze spatial learning and memory deficits in GALT-deficient SD rats.
- Protocol → model：GALT-deficient classic galactosemia model (SD rat)：
  Age：Adult 4-5 months of age
- Protocol → model：GALT-deficient classic galactosemia model (SD rat)：
  Tissue：brain (behavior)
- Model → research topic：GALT-deficient classic galactosemia model (SD rat) → metabolic disease：
  A GALT deficiency model of classic galactosemia for studying tissue galactose metabolites, cataracts, growth, and neurobehavioral phenotypes.
Show 7 model association(s)
Wistar ICV-STZ rat · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 32336744; DOI: 10.1538/expanim.19-0146. The original text uses fixed-platform training and off-platform probe trials; this source explicitly specifies implementation in Wistar rats, but it is an automatically elevating platform variant with daily repositioning, and does not reproduce the original text's training duration, water temperature, interventions, or number of platform crossings. The specific execution follows protocols.io e6nvwn832vmk/v1; age and sex are the cohort background of the cited model study and are not fixed requirements of this source protocol.
Age：3–4 months of ageSex：MaleTissue：Wistar ICV-STZ rats; the original study used male animals.
Evaluating the spatial learning and localization performance of Wistar ICV-STZ rats using the water maze platform latency and swimming trajectories.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1538/expanim.19-0146
Study the connections among brain energy metabolism, neural injury, and cognitive function, and evaluate the effects of candidate interventions on the relevant phenotypes.
TgF344-AD · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 29107184; DOI: 10.1016/j.neurobiolaging.2017.09.024. The original text explicitly implemented a matching-to-place task with daily platform changes, but the waiting interval and the source of the automated elevating platform differ. The original study found no significant spatial learning and memory deficits in young adult animals, so it cannot be presumed that this age necessarily involves impairment. The specific execution follows protocols.io e6nvwn832vmk/v1; age and sex are cohort background from the cited model study and are not fixed requirements of this source protocol.
Age：4.29–6.52 months of ageSex：MixedTissue：TgF344-AD rats; the original study included male and female animals and wild-type controls.
Compare the platform-reaching latency in successive place navigation trials to evaluate the spatial relearning performance of TgF344-AD rats.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1016/j.neurobiolaging.2017.09.024
Investigate the associations between early behavioral changes, working memory, and structural or functional brain networks, and explore the joint evaluation of imaging and cognitive metrics.
McGill-R-Thy1-APP · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 29097597; DOI: 10.1523/JNEUROSCI.1346-17.2017. The original study used fixed-platform reference memory, platform removal, and a visible-platform control; this procedure is an independent reference implementation with an automated elevating platform repositioned daily, and the parameters and outcomes of the two cannot be interchanged. The specific execution follows protocols.io e6nvwn832vmk/v1; age and sex are the cohort background of the cited model study and are not fixed requirements of that source protocol.
Age：9–11 months of age and 16–19 months of ageSex：MixedTissue：McGill-R-Thy1-APP homozygous rats; the original study included male and female animals and WT Wistar controls.
Evaluate the spatial learning and memory of McGill-R-Thy1-APP rats using water maze positioning performance, and note the impact of visual and swimming abilities on behavioral readouts.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1523/JNEUROSCI.1346-17.2017
A longitudinal study of the relationship between Aβ accumulation, spatial memory, brain network connectivity, and PET metabolic or amyloid signals.
Sprague-Dawley ICV-STZ rat · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:42797438; DOI:10.3390/ph19091392. The original study was a fixed-platform learning and platform-removal probe trial; this association uses an automated rising/falling platform reference procedure with daily position changes and does not reproduce the original water temperature, number of training sessions, drug intervention, or probe trial. The specific execution follows protocols.io e6nvwn832vmk/v1; age and sex are the cohort background of the cited model study and are not fixed requirements of this source protocol.
Age：AdultSex：FemaleTissue：Sprague–Dawley ICV-STZ rats; the original study used adult female animals.
Evaluate spatial positioning and relearning based on the latency to the platform and swimming trajectories, focusing on the spatial learning and memory performance of the model.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.7150/thno.81951
Investigate the connections among astrocytes, AQP4 polarized distribution, Aβ clearance, and cognitive function, as well as the effects of candidate interventions on these phenotypes.
SD rat MCAO suture model · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:23845275; https://pubmed.ncbi.nlm.nih.gov/23845275/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Assessment of long-term spatial learning and memory using the Morris water maze after transient MCAO in SD rats.
Related research topics: 1 (1 verified · 0 candidate)
· ischemic stroke · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:9407391; https://pubmed.ncbi.nlm.nih.gov/9407391/; DOI:10.1007/bf02736854
The transient MCAO reperfusion model in SD rats is used for the study of ischemic brain injury.
transient middle cerebral artery occlusion Wistar rat · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:29121965; https://pubmed.ncbi.nlm.nih.gov/29121965/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Morris water maze was used to assess spatial learning and memory in Wistar rats after MCAO.
Related research topics: 1 (1 verified · 0 candidate)
· ischemic stroke · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1186/s12974-017-0992-5
Transient MCAO for 90 min without BCCAo served as the stroke-only comparison group.
GALT-deficient classic galactosemia model (SD rat) · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:31845342; https://pubmed.ncbi.nlm.nih.gov/31845342/
Age：Adult 4-5 months of ageSex：MaleTissue：brain (behavior)
Evaluation of Morris water maze spatial learning and memory deficits in GALT-deficient SD rats.
Related research topics: 1 (1 verified · 0 candidate)
· metabolic disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:31845342; https://pubmed.ncbi.nlm.nih.gov/31845342/
A GALT deficiency model of classic galactosemia for studying tissue galactose metabolites, cataracts, growth, and neurobehavioral phenotypes.
Morris water maze assessment of spatial learning and memory in miceprotocol #188 · revision 12
Source version：protocols.io · v1 · Sarah van Veen; Zsuzsanna Callaerts-Végh · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Learning and Memory Assessment
This reagent's uses & amounts
- Training trials · Dry animals after removal from the water between maze trials, following the warming arrangements in the applicable protocol. · Not reported in the source · The source guidelines require a warm towel for drying animals; material, dimensions and quantity per animal are not reported.
Associated models: 1515 protocol→model record(s)15 verified · 0 candidate
Model → research topic：12 verified · 3 candidate。These statuses apply to individual relationships, not to this reagent.
Recorded use and applicability limits
- Protocol → model：bilateral common carotid artery stenosis C57BL/6J mouse：
  Morris water maze assessment of spatial learning and memory in C57BL/6J mice after chronic hypoperfusion induced by bilateral common carotid artery stenosis.
- Protocol → model：bilateral common carotid artery stenosis C57BL/6J mouse：
  Age：Adult (specific age in weeks not reported by the source)
- Protocol → model：bilateral common carotid artery stenosis C57BL/6J mouse；Protocol → model：asymmetric common carotid artery surgery C57BL/6J mouse；Protocol → model：bilateral common carotid artery stenosis C57BL/6 mouse；Protocol → model：permanent distal middle cerebral artery occlusion C57BL/6J mouse；Protocol → model：transient middle cerebral artery occlusion C57BL/6J mouse；Protocol → model：C57 mouse MCAO suture model：
  Tissue：Brain/Hippocampus (spatial learning and memory)
- Model → research topic：bilateral common carotid artery stenosis C57BL/6J mouse → ischemic stroke：
  Bilateral common carotid artery stenosis produces chronic hypoperfusion and white-matter injury in C57BL/6J mice; it is not an acute focal MCA infarct model.
- Protocol → model：asymmetric common carotid artery surgery C57BL/6J mouse：
  Assessment of spatial learning and memory using the Morris water maze after unilateral common carotid artery surgery in C57BL/6J mice.
- Protocol → model：asymmetric common carotid artery surgery C57BL/6J mouse；Protocol → model：bilateral common carotid artery stenosis C57BL/6 mouse；Protocol → model：permanent distal middle cerebral artery occlusion C57BL/6J mouse；Protocol → model：transient middle cerebral artery occlusion C57BL/6J mouse；Protocol → model：C57 mouse MCAO suture model：
  Age：Adult (specific age in weeks not reported by source)
- Model → research topic：asymmetric common carotid artery surgery C57BL/6J mouse → ischemic stroke：
  Asymmetric common carotid artery surgery produces chronic white-matter infarct-related damage and cognitive/motor dysfunction; it is a hypoperfusion reference model, not acute territorial stroke.
- Protocol → model：bilateral common carotid artery stenosis C57BL/6 mouse：
  Research on spatial learning and memory associated with chronic cerebral hypoperfusion.
- Model → research topic：bilateral common carotid artery stenosis C57BL/6 mouse → ischemic stroke：
  Bilateral common carotid artery stenosis produces chronic hypoperfusion and white-matter injury in C57BL/6 mice; it is a hypoperfusion reference model, not an acute focal MCA infarct.
- Protocol → model：permanent distal middle cerebral artery occlusion C57BL/6J mouse：
  Assessment of long-term spatial memory recovery using the Morris water maze after permanent distal MCAO in C57BL/6J mice.
- Model → research topic：permanent distal middle cerebral artery occlusion C57BL/6J mouse → ischemic stroke：
  Study on White Matter Repair and Functional Recovery After Permanent Distal Middle Cerebral Artery Occlusion in C57BL/6J Mice.
- Protocol → model：transient middle cerebral artery occlusion C57BL/6J mouse：
  Morris water maze assessment of spatial learning and memory after MCAO in C57BL/6J mice.
- Model → research topic：transient middle cerebral artery occlusion C57BL/6J mouse → ischemic stroke：
  Male C57BL/6J mice subjected to 90 min intraluminal MCAO; sham mice underwent identical surgery without filament insertion.
- Protocol → model：C57 mouse MCAO suture model：
  Morris water maze was used to assess spatial learning and memory in C57BL/6 mice after MCAO.
- Model → research topic：C57 mouse MCAO suture model → ischemic stroke：
  Transient MCAO reperfusion model in C57 mice for the study of ischemic brain injury.
- Protocol → model：3xTg-AD transgenic model；Protocol → model：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP)；Protocol → model：J20 transgenic amyloidosis model (APPSwInd, PDGFB)；Protocol → model：5xFAD transgenic model；Protocol → model：Tg2576 transgenic amyloid model (APP695 Swedish)；Protocol → model：App NL：
  Spatial learning and reference memory assessment.
- Protocol → model：3xTg-AD transgenic model：
  Age：Intervention started at 3 months of age, followed by behavioral testing
- Protocol → model：3xTg-AD transgenic model；Protocol → model：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP)；Protocol → model：J20 transgenic amyloidosis model (APPSwInd, PDGFB)；Protocol → model：5xFAD transgenic model；Protocol → model：Tg2576 transgenic amyloid model (APP695 Swedish)；Protocol → model：App NL：
  Tissue：Live mice (behavioral studies)
- Model → research topic：3xTg-AD transgenic model → Alzheimer disease：
  The 3xTg-AD transgenic model is used for research on Alzheimer's disease-related amyloid and tau pathology.
- Protocol → model：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP)：
  Age：77–85 days of age
- Protocol → model：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP)；Protocol → model：APOE4；Protocol → model：rTg4510：
  Sex：Mixed
- Model → research topic：TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP) → Alzheimer disease：
  Intervention Study of Early-Onset Strong Amyloid Deposition and Cognitive Impairment Paradigm (TgCRND8)
- Protocol → model：J20 transgenic amyloidosis model (APPSwInd, PDGFB)：
  Age：4–6 months of age
- Protocol → model：J20 transgenic amyloidosis model (APPSwInd, PDGFB)；Protocol → model：Tg2576 transgenic amyloid model (APP695 Swedish)：
  Sex：Female
- Model → research topic：J20 transgenic amyloidosis model (APPSwInd, PDGFB) → Alzheimer disease：
  J20 (APP Swedish+Indiana double mutation, PDGFB promoter) reference model for amyloid pathology and synaptotoxicity studies; applicability is limited to JAX strain records and PMID:10818140 controlled studies
- Protocol → model：5xFAD transgenic model：
  Age：4. 9 months of age
- Model → research topic：5xFAD transgenic model → Alzheimer disease：
  The 5xFAD transgenic model is used for research on Alzheimer's disease-related amyloid pathology and neurodegenerative changes.
- Protocol → model：Tg2576 transgenic amyloid model (APP695 Swedish)：
  Age：20 months of age
- Model → research topic：Tg2576 transgenic amyloid model (APP695 Swedish) → Alzheimer disease：
  Age-dependent memory decline and amyloid plaque study driven by APP Swedish mutation overexpression (Tg2576)
- Protocol → model：App NL：
  Age：24 months of age
- Protocol → model：App NL：
  Sex：Male
- Model → research topic：App NL → Alzheimer disease：
  Investigate the relationship between App Swedish mutation, Aβ oligomer accumulation, and cognitive phenotype.
- Protocol → model：APOE4：
  In recipients receiving bone marrow cells from APP/PS1 and human APOE4 background donors, the Morris water maze was used to evaluate human APOE4-related changes in spatial learning and reference memory, and swimming speed was incorporated to distinguish the influence of locomotor ability.
- Protocol → model：APOE4：
  Age：Bone marrow cell transplantation at 3 months of age, evaluation at 12 months of age
- Protocol → model：APOE4：
  Tissue：Live mice; spatial learning and memory assessment in the context of bone marrow transplantation
- Model → research topic：APOE4 → Alzheimer disease：
  To study the effects of APOE4 on peripheral Aβ brain transport, the blood-brain barrier, and cognitive performance.
- Protocol → model：Tg4-42：
  The water maze was used to evaluate spatial learning and reference memory in Tg4-42 mice, to distinguish between different ages in months and zygosity, and to assess sensorimotor factors through the visible platform and swimming speed.
- Protocol → model：Tg4-42：
  Age：Hemizygous at 3, 8, and 12 months of age; homozygous at 3 and 8 months of age
- Protocol → model：Tg4-42：
  Tissue：Live mice; evaluation of spatial learning and reference memory
- Model → research topic：Tg4-42 → Alzheimer disease：
  To study Aβ4-42-related alterations in hippocampal neurogenesis, as well as the effects of activity conditions on the structure of the dentate gyrus and neuronal generation.
- Protocol → model：rTg4510：
  Evaluate the spatial learning and reference memory of rTg4510 mice using the water maze, and combine with the visible platform and swimming speed to check sensorimotor factors; the genetic backgrounds compared in the study are explained separately.
- Protocol → model：rTg4510：
  Age：2.5 months of age
- Protocol → model：rTg4510：
  Tissue：Live mice; F1 FVB/N×129S6 and separately compared rTg4510B6 background
- Model → research topic：rTg4510 → Alzheimer disease：
  Study the staged effects of tau pathology, neurodegeneration, and tau expression suppression; not suitable for evaluating Aβ pathology alone.
Show 15 model association(s)
bilateral common carotid artery stenosis C57BL/6J mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:31817864; https://pubmed.ncbi.nlm.nih.gov/31817864/
Age：Adult (specific age in weeks not reported by the source)Tissue：Brain/Hippocampus (spatial learning and memory)
Morris water maze assessment of spatial learning and memory in C57BL/6J mice after chronic hypoperfusion induced by bilateral common carotid artery stenosis.
Related research topics: 1 (0 verified · 1 candidate)
· ischemic stroke · Candidate (not internally validated)
This model's applicability to this disease
Status：Candidate (not internally validated)· Evidence type：Literature evidence· Source：PMID:31817864; https://pubmed.ncbi.nlm.nih.gov/31817864/
Bilateral common carotid artery stenosis produces chronic hypoperfusion and white-matter injury in C57BL/6J mice; it is not an acute focal MCA infarct model.
asymmetric common carotid artery surgery C57BL/6J mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:31817864; https://pubmed.ncbi.nlm.nih.gov/31817864/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Assessment of spatial learning and memory using the Morris water maze after unilateral common carotid artery surgery in C57BL/6J mice.
Related research topics: 1 (0 verified · 1 candidate)
· ischemic stroke · Candidate (not internally validated)
This model's applicability to this disease
Status：Candidate (not internally validated)· Evidence type：Literature evidence· Source：PMID:31817864; https://pubmed.ncbi.nlm.nih.gov/31817864/
Asymmetric common carotid artery surgery produces chronic white-matter infarct-related damage and cognitive/motor dysfunction; it is a hypoperfusion reference model, not acute territorial stroke.
bilateral common carotid artery stenosis C57BL/6 mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/31817864/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Research on spatial learning and memory associated with chronic cerebral hypoperfusion.
Related research topics: 1 (0 verified · 1 candidate)
· ischemic stroke · Candidate (not internally validated)
This model's applicability to this disease
Status：Candidate (not internally validated)· Evidence type：Literature evidence· Source：PMID:34797519; https://pubmed.ncbi.nlm.nih.gov/34797519/
Bilateral common carotid artery stenosis produces chronic hypoperfusion and white-matter injury in C57BL/6 mice; it is a hypoperfusion reference model, not an acute focal MCA infarct.
permanent distal middle cerebral artery occlusion C57BL/6J mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:42529831; https://pubmed.ncbi.nlm.nih.gov/42529831/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Assessment of long-term spatial memory recovery using the Morris water maze after permanent distal MCAO in C57BL/6J mice.
Related research topics: 1 (1 verified · 0 candidate)
· ischemic stroke · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/42529831/
Study on White Matter Repair and Functional Recovery After Permanent Distal Middle Cerebral Artery Occlusion in C57BL/6J Mice.
transient middle cerebral artery occlusion C57BL/6J mouse · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:42677156; https://pubmed.ncbi.nlm.nih.gov/42677156/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Morris water maze assessment of spatial learning and memory after MCAO in C57BL/6J mice.
Related research topics: 1 (1 verified · 0 candidate)
· ischemic stroke · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1186/s13041-017-0296-9
Male C57BL/6J mice subjected to 90 min intraluminal MCAO; sham mice underwent identical surgery without filament insertion.
C57 mouse MCAO suture model · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:42544301; https://pubmed.ncbi.nlm.nih.gov/42544301/
Age：Adult (specific age in weeks not reported by source)Tissue：Brain/Hippocampus (spatial learning and memory)
Morris water maze was used to assess spatial learning and memory in C57BL/6 mice after MCAO.
Related research topics: 1 (1 verified · 0 candidate)
· ischemic stroke · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:37786756; https://pubmed.ncbi.nlm.nih.gov/37786756/; DOI:10.1002/ibra.12128
Transient MCAO reperfusion model in C57 mice for the study of ischemic brain injury.
3xTg-AD transgenic model · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/29725016/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：Intervention started at 3 months of age, followed by behavioral testingTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:12895417; https://pubmed.ncbi.nlm.nih.gov/12895417/; DOI:10.1016/s0896-6273(03)00434-3
The 3xTg-AD transgenic model is used for research on Alzheimer's disease-related amyloid and tau pathology.
TgCRND8 transgenic amyloid model (Swedish+Indiana, PrP) · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/26902204/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：77–85 days of ageSex：MixedTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:37887303; DOI:10.3390/cells12202459; https://pubmed.ncbi.nlm.nih.gov/37887303/
Intervention Study of Early-Onset Strong Amyloid Deposition and Cognitive Impairment Paradigm (TgCRND8)
J20 transgenic amyloidosis model (APPSwInd, PDGFB) · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/28700937/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：4–6 months of ageSex：FemaleTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:10818140; DOI:10.1523/JNEUROSCI.20-11-04050.2000; https://pubmed.ncbi.nlm.nih.gov/10818140/
J20 (APP Swedish+Indiana double mutation, PDGFB promoter) reference model for amyloid pathology and synaptotoxicity studies; applicability is limited to JAX strain records and PMID:10818140 controlled studies
5xFAD transgenic model · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/26942905/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：4. 9 months of ageTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:17021169; https://pubmed.ncbi.nlm.nih.gov/17021169/; DOI:10.1523/jneurosci.1202-06.2006
The 5xFAD transgenic model is used for research on Alzheimer's disease-related amyloid pathology and neurodegenerative changes.
Tg2576 transgenic amyloid model (APP695 Swedish) · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/25100745/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：20 months of ageSex：FemaleTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID:8810256; DOI:10.1126/science.274.5284.99; https://pubmed.ncbi.nlm.nih.gov/8810256/
Age-dependent memory decline and amyloid plaque study driven by APP Swedish mutation overexpression (Tg2576)
App NL · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：https://pubmed.ncbi.nlm.nih.gov/30320577/ ; https://doi.org/10.17504/protocols.io.5jyl84zk7g2w/v1
Age：24 months of ageSex：MaleTissue：Live mice (behavioral studies)
Spatial learning and reference memory assessment.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.3233/JAD-180410
Investigate the relationship between App Swedish mutation, Aβ oligomer accumulation, and cognitive phenotype.
APOE4 · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 40906458, Methods and Materials and Figure 7: 3-month-old recipients were transplanted, cognitive assessment was performed at 12 months of age, and males and females were used in a balanced manner; the recipient APOE4 genotype and the transplantation background were each retained. PIO5jyl84zk7g2w/v1 was used as the mouse reference for implementation, not as a parameter-by-parameter reproduction of the original article; no claim is made that the original article used ACUSOL OP301.
Age：Bone marrow cell transplantation at 3 months of age, evaluation at 12 months of ageSex：MixedTissue：Live mice; spatial learning and memory assessment in the context of bone marrow transplantation
In recipients receiving bone marrow cells from APP/PS1 and human APOE4 background donors, the Morris water maze was used to evaluate human APOE4-related changes in spatial learning and reference memory, and swimming speed was incorporated to distinguish the influence of locomotor ability.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1111/acel.70205
To study the effects of APOE4 on peripheral Aβ brain transport, the blood-brain barrier, and cognitive performance.
Tg4-42 · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 23685882, PMC3722453, Spatial reference memory by Morris water maze: hemizygotes at 3/8/12 months of age, homozygotes at 3/8 months of age; sex was matched between groups but the specific sex composition of this cohort was not reported. The complete reference memory protocol of PIO5jyl84zk7g2w/v1 was used, not a parameter-by-parameter reproduction of the original article; it is not inferred that the original article used ACUSOL OP301.
Age：Hemizygous at 3, 8, and 12 months of age; homozygous at 3 and 8 months of ageTissue：Live mice; evaluation of spatial learning and reference memory
The water maze was used to evaluate spatial learning and reference memory in Tg4-42 mice, to distinguish between different ages in months and zygosity, and to assess sensorimotor factors through the visible platform and swimming speed.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.1177/1759091419892692
To study Aβ4-42-related alterations in hippocampal neurogenesis, as well as the effects of activity conditions on the structure of the dentate gyrus and neuronal generation.
rTg4510 · Verified applicability
This protocol's applicability to this model
Status：Verified applicability· Evidence type：Literature evidence· Source：PMID: 24428919, PMC3896770, Mice and Morris water maze: 2.5-month-old rTg4510, rTg4510B6, and non-transgenic littermate controls, both males and females included; the original and B6 variant backgrounds were not mixed into a single strain. Implemented using the PIO5jyl84zk7g2w/v1 reference, not a parameter-by-parameter reproduction of the original article; no claim is made that the original article used ACUSOL OP301.
Age：2.5 months of ageSex：MixedTissue：Live mice; F1 FVB/N×129S6 and separately compared rTg4510B6 background
Evaluate the spatial learning and reference memory of rTg4510 mice using the water maze, and combine with the visible platform and swimming speed to check sensorimotor factors; the genetic backgrounds compared in the study are explained separately.
Related research topics: 1 (1 verified · 0 candidate)
· Alzheimer disease · Verified applicability
This model's applicability to this disease
Status：Verified applicability· Evidence type：Literature evidence· Source：https://doi.org/10.3390/biomedicines14071609
Study the staged effects of tau pathology, neurodegeneration, and tau expression suppression; not suitable for evaluating Aβ pathology alone.

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