2型糖尿病 (T2D)

Applicable models (published, verified)

• db/db (Lepr^db) · db/db 模型用于肥胖相关胰岛素抵抗和2型糖尿病研究，适用性受遗传背景影响。 · Verified applicability
• ob/ob (Lep^ob) · ob/ob 模型用于肥胖、胰岛素抵抗与2型糖尿病相关代谢研究，糖尿病表型受遗传背景影响。 · Verified applicability
• CC G×E 多品系队列 (NZO 背景) · CC多品系在饮食条件下与T2D相关的体重、葡萄糖代谢及宿主遗传背景互作的文献参考用途。所引研究使用CC037、CC019、CC010、CC005及C57BL/6对照；其结果不据此证明本条所称“NZO背景”队列的具体组成或公司资源身份。 · Verified applicability
• 饮食诱导肥胖（DIO）模型（文献参考） · 2型糖尿病饮食诱导肥胖与胰岛素抵抗研究的文献参考模型（DIO） · Verified applicability
• high-fat diet-fed C57BL/6J mouse · HFD group compared with chow-fed controls for metabolic and renal outcomes. · Verified applicability
• Wistar fatty rat · Wistar fatty rats develop glucose intolerance accompanied by exaggerated insulin secretion, hypertrophied islets with degranulation of β cells, albuminuria and decreased GFR, increased ICAM-1 expression and renal hypertrophy. · Verified applicability
• high-fat diet plus low-dose streptozotocin-induced type 2 diabetes rodent · How can diet and low-dose streptozotocin be combined to model type 2 diabetes?; rodents fed high caloric diets with low-dose STZ · Verified applicability
• Zucker diabetic Sprague-Dawley (ZDSD) rat · Which rodent models and endpoints have been used to study obesity, type 1 diabetes, type 2 diabetes and diabetic peripheral neuropathy, and what are their limitations?; Zucker diabetic Sprague-Dawley rats. · Verified applicability
• ob/ob C57BL/6 mouse · The review evaluates monogenic obesity models for T2D.; Published ob/ob mouse studies. · Verified applicability
• Goto-Kakizaki rat · Does resveratrol improve glucose tolerance, tissue lipid handling and pancreatic islet structure in Goto-Kakizaki rats?; GK rats · Verified applicability
• db/db C57BLKS mouse · Which renal and metabolic abnormalities develop in db/db mice; db/db mouse kidney and urine at 12 weeks · Verified applicability
• high-fat diet plus low-dose streptozotocin-induced type 2 diabetes C57BL/6J mouse · How chromatin accessibility, transcript isoforms and RNA modifications are remodeled in diabetic cardiomyopathy.; Whether HFD/STZ mice develop diabetic cardiomyopathy with transcriptional and epigenetic remodeling. · Verified applicability
• high-fat diet plus streptozotocin-induced type 2 diabetes C57BL/6J mouse · Does aerobic exercise alleviate diabetic arterial remodeling through Sirt1?; Male C57BL/6J mice, 6 weeks old; CON, CON-Exe, T2DM and T2DM-Exe groups · Verified applicability
• university of california davis type 2 diabetes mellitus UCD-T2DM rat · How is diabetes defined and staged in the UCD-T2DM rat?; UCD-T2DM rats under regular chow or high-fat diet, with fed or fasting blood glucose monitoring. · Verified applicability
• high-fat diet plus streptozotocin-induced type 2 diabetes C57BL/6 mouse · Does the STZ-HFD model produce more intervertebral disc inflammation and degeneration than db/db?; Intervertebral discs from male C57BL/6 mice, 12 weeks old at start, n=13 STZ-HFD and n=7 vehicle controls · Verified applicability
• ob/ob mouse · Does suppressing Lpcat3 improve insulin resistance and lipid metabolism in diet-induced and genetic obese diabetic mice?; 6-7-week-old ob/ob mice · Verified applicability
• high-fat diet-induced obesity mouse · Whether PTPN1/PTPN2 inhibition induces weight loss in diet-induced obesity with an intact but resistant leptin axis; DIO mice, n = 5 per group, 6-week treatment plus 2-week withdrawal · Verified applicability
• Otsuka Long-Evans Tokushima Fatty (OLETF) rat · Recommendation that diabetic rat models remain essential for developing novel drugs and understanding human diabetes.; Review-level conclusion. · Verified applicability
• Spontaneously Diabetic Torii (SDT) rat · Which rat model most closely resembles human DR pathophysiology?; Review of spontaneously diabetic Torii rats · Verified applicability
• t2dn/mcwi rat · Is the T2DN/Mcwi rat suitable for advanced diabetic nephropathy research?; T2DN/Mcwi rat · Verified applicability
• Spontaneously Diabetic Torii (SDT) fatty rat · Pathophysiological features of diabetes and its complications in obese T2D rat models.; Review-level synthesis across models. · Verified applicability
• KK-Ay mouse · What stages of diabetic nephropathy does the KK-Ay mouse reproduce?; KK-Ay mouse · Verified applicability
• ob/ob BTBR mouse · Which rodent models and phenotyping methods are appropriate for experimental diabetic nephropathy?; diabetic nephropathy models · Verified applicability
• high-fat diet plus low-dose streptozotocin-induced type 2 diabetes Wistar rat · Does MOTS-c restore cardiac mitochondrial respiration in type 2 diabetic rats?; Male Wistar rats, 6-7 weeks old and 150-200 g, fed a high-fat diet for 15 weeks with a 25 mg/kg streptozotocin injection at week 8 · Verified applicability
• Zucker diabetic fatty (ZDF) rat · Review of pancreatic, renal, ocular, neural, bone and gonadal complications in obese T2D rat models.; Review-level synthesis of ZDF studies. · Verified applicability
• db/db mouse · Which metabolic and renal abnormalities develop in db/db mice; kidney tissue, urine and serum from db/db mice · Verified applicability
• high-fat diet-induced obesity and diabetes C57BL/6J mouse · Does liver-directed AAV-BMP7 reverse diet-induced obesity and insulin resistance?; Male C57BL/6J mice fed chow or HFD for 6 weeks from 2 months of age, then followed about 6 months · Verified applicability
• high-fat diet plus low-dose streptozotocin-induced type 2 diabetes Sprague-Dawley rat · Whether DMT1-mediated iron transport in bone contributes to the bone microstructure and biomechanical deterioration of type 2 diabetic osteoporosis.; Tibia of male Sprague-Dawley rats, 3 months old at purchase, fed high-fat diet for two months then given 30 mg/kg intraperitoneal streptozotocin, studied at 8 months of age; n=10 per group. · Verified applicability
• High-fat diet-fed C57BL/6 mouse · Does loss of CD226 alter high-fat diet-induced obesity and adipose tissue macrophage inflammation?; Wild-type C57BL/6 littermates fed a 60% fat HFD for 16 weeks starting at 5-6 weeks of age · Verified applicability
• SHR/N-corpulent (SHR/N-cp) rat · How relevant and translatable are leptin- and leptin receptor-deficient rodent models to human type 2 diabetes?; Narrative review of published studies on leptin- and leptin receptor-deficient rodents; no animals used in this study · Verified applicability
• Tcf7l2 whole-body knockout mouse (reference model) · What whole-body loss of Tcf7l2 reveals about T2D risk gene function.; Constitutive Tcf7l2 −/− mice. · Verified applicability
• ZnT8 (Slc30a8) systemic knockout mouse · What systemic ZnT8 loss reveals about insulin processing and glucose homeostasis.; Systemic ZnT8 knockout mice from several colonies. · Verified applicability
• pancreas-specific Tcf7l2 knockout mouse (Pdx1-Cre) · Whether pancreatic Tcf7l2 deletion impairs glucose homeostasis.; Pancreas-specific Tcf7l2 knockout mice. · Verified applicability
• alpha cell-specific ZnT8 knockout mouse · Whether α cell ZnT8 deletion affects glucose tolerance.; α cell-specific ZnT8 null mice. · Verified applicability
• beta cell-specific Tcf7l2 knockout mouse (RIP2.Cre-ER T2, tamoxifen-inducible) · Whether β cell-specific Tcf7l2 deletion reproduces the islet phenotype.; βTCF4KO mice on normal or high-fat diet. · Verified applicability
• beta cell-specific ZnT8 knockout mouse (RIP2 promoter) · Whether β cell ZnT8 deletion accounts for the systemic knockout phenotype.; β cell-specific ZnT8 null mice. · Verified applicability
• high-fat diet-fed Wistar rat · What hepatic and adipose responses do Wistar rats show to moderate-duration HFD?; Reviewed studies of Wistar rats fed 45% lard-based diet for 4-15 weeks · Verified applicability
• high-fat diet-induced obesity Sprague-Dawley rat · Which rodent models and endpoints have been used to study obesity, type 1 diabetes, type 2 diabetes and diabetic peripheral neuropathy, and what are their limitations?; High-fat diet-fed Sprague-Dawley rats. · Verified applicability
• Zucker fatty (fa/fa) rat · Which rodent models and endpoints have been used to study obesity, type 1 diabetes, type 2 diabetes and diabetic peripheral neuropathy, and what are their limitations?; Obese Zucker (fa/fa) rats. · Verified applicability
• JCR:LA-corpulent (JCR:LA-cp) rat · How relevant and translatable are leptin- and leptin receptor-deficient rodent models to human type 2 diabetes?; Narrative review of published studies on leptin- and leptin receptor-deficient rodents; no animals used in this study · Verified applicability
• 45% high-fat diet Western-like rodent model · Review-recommended model that most closely recapitulates human Western diet and progressive T2D phenotype · Verified applicability
• high carbohydrate diet-induced rat model · Review-recommended model for early MS stages with mild FBG effect but significant hypertriglyceridemia and IR · Verified applicability
• high carbohydrate-high fat diet-induced rat model (cafeteria diet) · Review-recommended cafeteria-style HCH-HFD as the most robust model inducing obesity, dyslipidemia, IR, hyperglycemia and inflammation · Verified applicability
• high fat diet-induced rat model · Review-recommended 30-50% HFD as the model of choice to simulate a condition close to T2DM within 10+ weeks · Verified applicability
• neonatal streptozotocin followed by high-fat diet mouse · Streptozotocin-induced diabetes combined with HFD is used as a NAFLD model · Verified applicability
• high-fat diet plus streptozotocin-induced type 2 diabetes mouse (adult induction) · Adult high-fat diet plus streptozotocin mouse research on hyperglycemia and diabetic kidney injury. · Verified applicability